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BPC157 – 5mg

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5 mg per vial

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Properties

Molecular Formula

C62H98N16O22

Molecular Weight 1419.5
Monoisotopic Mass 1417.70415882
Polar Area 574
Complexity3040
XLogP -9
Heavy Atom Count 100
Hydrogen Bond Donor Count 16
Hydrogen Bond Acceptor Count 24
Rotatable Bond Count 39
Physical Appearance Fine White Lyophilized Powder
StabilityLyophilized protein is to be stored at -20°C. It is recommended to aliquot the reconstituted (dissolved) protein into several discrete vials in order to avoid repeated freezing and thawing. Reconstituted protein can be stored at 4°C
PubChem LCSS

BPC – 157 Laboratory Chemical Safety Summary

Identifiers

CID9941957
CAS137525-51-0
InChI InChI=1S/C62H98N16O22/c1-31(2)25-37(55(92)74-50(32(3)4)62(99)100)71-46(81)29-65-51(88)33(5)67-53(90)38(26-48(84)85)73-54(91)39(27-49(86)87)72-52(89)34(6)68-57(94)41-15-10-21-75(41)58(95)35(13-7-8-20-63)70-45(80)30-66-56(93)40-14-9-22-76(40)60(97)43-17-12-24-78(43)61(98)42-16-11-23-77(42)59(96)36(18-19-47(82)83)69-44(79)28-64/h31-43, 50H, 7-30, 63-64H2, 1-6H3, (H, 65, 88)(H, 66, 93)(H, 67, 90)(H, 68, 94)(H, 69, 79)(H, 70, 80)(H, 71, 81)(H, 72, 89)(H, 73, 91)(H, 74, 92)(H, 82, 83)(H, 84, 85)(H, 86, 87)(H, 99, 100)/t33-, 34-, 35-, 36-, 37-, 38-, 39-, 40-, 41-, 42-, 43-, 50-/m0/s1
InChIKeyHEEWEZGQMLZMFE-RKGINYAYSA-N
Isomeric SMILES C[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@@H]2CCCN2C(=O)[C@@H]3CCCN3C(=O)[C@@H]4CCCN4C(=O)[C@H](CCC(=O)O)NC(=O)CN
Canonical SMILES CC(C)CC(C(=O)NC(C(C)C)C(=O)O)NC(=O)CNC(=O)C(C)NC(=O)C(CC(=O)O)NC(=O)C(CC(=O)O)NC(=O)C(C)NC(=O)C1CCCN1C(=O)C(CCCCN)NC(=O)CNC(=O)C2CCCN2C(=O)C3CCCN3C(=O)C4CCCN4C(=O)C(CCC(=O)O)NC(=O)CN
IUPAC Name (4S)-4-[(2-aminoacetyl)amino]-5-[(2S)-2-[(2S)-2-[(2S)-2-[[2-[[(2S)-6-amino-1-[(2S)-2-[[(2S)-1-[[(2S)-3-carboxy-1-[[(2S)-3-carboxy-1-[[(2S)-1-[[2-[[(2S)-1-[[(1S)-1-carboxy-2-methylpropyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxohexan-2-yl]amino]-2-oxoethyl]carbamoyl]pyrrolidine-1-carbonyl]pyrrolidine-1-carbonyl]pyrrolidin-1-yl]-5-oxopentanoic acid

Description

BPC157 Peptide: Advancing Research in Healing and Recovery

NuScience Peptides sells research products only, they are not for human consumption.

BPC-157, also known as Body Protection Compound-157, is a synthetic peptide consisting of 15 amino acids. It is derived from a protective protein found in the stomach and has been extensively researched for its potential therapeutic effects on various tissues, including muscles, tendons, ligaments, and the gastrointestinal tract. This white paper aims to provide a comprehensive overview of BPC-157, including its mechanisms of action, therapeutic applications, safety profile, and potential future research directions.

Mechanisms of Action

BPC-157 exerts its effects through multiple mechanisms, making it a versatile therapeutic agent. Key mechanisms include:

  1. Angiogenesis and Vasculogenesis: BPC-157 promotes the formation of new blood vessels, enhancing blood flow to damaged tissues and facilitating healing processes.
  2. Anti-Inflammatory Effects: It reduces inflammation by modulating the release of pro-inflammatory cytokines and increasing the production of anti-inflammatory mediators.
  3. Cell Proliferation and Migration: BPC-157 stimulates the proliferation and migration of various cell types, including fibroblasts and endothelial cells, which are crucial for tissue repair.
  4. Neuroprotective Effects: It has been shown to protect nerve cells from damage and promote nerve regeneration.
  5. Gastroprotective Effects: BPC-157 has a protective effect on the gastrointestinal tract, enhancing the integrity of the mucosal barrier and promoting the healing of ulcers.

Therapeutic Applications

Research on BPC-157 has highlighted its potential in treating a variety of conditions:

  1. Musculoskeletal Injuries:
    • Tendon and Ligament Healing: BPC-157 accelerates the healing of tendon and ligament injuries by promoting collagen synthesis and reducing inflammation.
    • Muscle Recovery: It enhances muscle regeneration and reduces recovery time after injury.
  2. Gastrointestinal Disorders:
    • Ulcer Healing: BPC-157 has been effective in healing gastric and intestinal ulcers by enhancing mucosal protection and promoting angiogenesis.
    • Inflammatory Bowel Disease (IBD): Preliminary studies suggest that BPC-157 may help manage IBD by reducing inflammation and promoting mucosal healing.
  3. Neurological Conditions:
    • Peripheral Neuropathy: BPC-157 shows promise in treating nerve damage by promoting nerve regeneration and reducing pain.
    • Central Nervous System (CNS) Injuries: Animal studies indicate potential benefits in CNS injuries, including spinal cord injury and traumatic brain injury.
  4. Cardiovascular Health:
    • Vascular Healing: BPC-157 promotes the healing of blood vessels and may help in conditions such as atherosclerosis and venous insufficiency.

Safety Profile

BPC-157 has demonstrated a high safety profile in both animal and human studies. Key points include:

  1. Toxicity: No significant toxicity has been observed at therapeutic doses in animal studies.
  2. Side Effects: Limited human studies report minimal side effects, primarily localized reactions at the injection site.
  3. Drug Interactions: Currently, there is no evidence of significant drug interactions, but more research is needed.

Future Research Directions

Despite promising results, further research is necessary to fully understand the therapeutic potential of BPC-157. Future research should focus on:

  1. Clinical Trials: Conducting large-scale, randomized controlled trials to confirm the efficacy and safety of BPC-157 in various conditions.
  2. Mechanistic Studies: Elucidating the precise molecular mechanisms by which BPC-157 exerts its effects.
  3. Long-term Safety: Assessing the long-term safety of BPC-157, especially with prolonged use.
  4. Combination Therapies: Exploring the potential synergistic effects of BPC-157 with other therapeutic agents.

Conclusion

BPC-157 is a promising therapeutic peptide with a broad range of potential applications, particularly in tissue repair and inflammation management. Its safety profile and multifaceted mechanisms of action make it a candidate for further clinical development. Continued research and clinical trials will be essential to fully realize the therapeutic potential of BPC-157 and integrate it into mainstream medical practice.

NuScience Peptides sells research products only, they are not for human consumption.

Synonyms:

BPC 157; BPC-157; Body protection compound 15;


Peer-Reviewed Sources:

  1. “Gastric pentadecapeptide BPC 157 as an original anti-ulcer agent and organoprotection peptide” – This study discusses BPC-157’s potential in protecting organs and healing ulcers. PubMed PMID: 8964320
  2. “Stable gastric pentadecapeptide BPC 157 as a prototype stable mediator, counteracting adrenergic activation and arrhythmias” – Investigates BPC-157’s effects on adrenergic activation and arrhythmias. PubMed PMID: 17131965
  3. “The effect of gastric pentadecapeptide BPC 157 on NSAID-induced damage” – Explores how BPC-157 mitigates damage caused by non-steroidal anti-inflammatory drugs. PubMed PMID: 10322125
  4. “Gastric pentadecapeptide BPC 157 in healing of segmental bone defect in rabbits” – Evaluates BPC-157’s efficacy in bone healing. PubMed PMID: 11124436
  5. “Gastric pentadecapeptide BPC 157 promotes the healing of transected rat Achilles tendon” – Investigates BPC-157’s role in tendon healing. PubMed PMID: 9575887
  6. “Gastric pentadecapeptide BPC 157 and the healing of transected quadriceps muscle in rats” – Focuses on muscle healing properties of BPC-157. PubMed PMID: 9855553
  7. “Stable gastric pentadecapeptide BPC 157: novel therapy in gastrointestinal tract” – Reviews BPC-157 as a therapeutic agent for gastrointestinal issues. PubMed PMID: 10875537
  8. “Gastric pentadecapeptide BPC 157 effective therapy for chronic alcohol-induced gastric lesions in rats” – Studies the effect of BPC-157 on alcohol-induced gastric lesions. PubMed PMID: 8597897

ALL LITERATURE, INFORMATION, AND DATA, PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY.

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Frequently Asked Questions

How can BPC-157 be used in research?

BPC-157 peptide is typically used in research to study its effects on healing and regeneration of muscles, tendons, ligaments, and the gastrointestinal tract. Researchers are also exploring its potential anti-inflammatory properties and its role in cellular repair mechanisms.

Is BPC-157 safe for research use?

When used according to proper research protocols, BPC-157 is generally considered safe for scientific studies. However, researchers must follow all relevant guidelines and regulations to ensure safe handling and application.

Can BPC-157 be used in human clinical trials?

BPC-157 is currently not approved by regulatory bodies such as the FDA for human clinical use. It is available strictly for research purposes, and any application in human trials must adhere to stringent regulatory approvals and ethical guidelines.

How should BPC-157 be stored?

BPC-157 should be stored in a cool, dry place, preferably in a refrigerator at temperatures between 2-8°C (35-46°F). Once reconstituted, it should be used promptly or stored according to specific storage guidelines to maintain its stability and effectiveness.

Do you provide documentation and certificates of analysis (COA) for BPC-157?

Yes, we provide comprehensive documentation, including certificates of analysis (COA), which detail the purity and composition of our BPC-157 products. This ensures researchers receive high-quality and reliable materials for their studies.

BPC157 Peptide

Accurate research is our priority.

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