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GHRP-6 – 5mg

Name: GHRP-6 - 5mg - NuScience Peptides
Price: 22.99 USD
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$22.99

5 mg per vial

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Properties

Molecular Formula	C₄₆H₅₆N₁₂O₆
Molecular Weight	873.0
Monoisotopic Mass	872.44457755
Polar Area	301
Complexity	1570
XLogP	1.9
Heavy Atom Count	64
Hydrogen Bond Donor Count	11
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	23
Physical Appearance	Clear Liquid
Stability	Lyophilized protein is to be stored at -20°C. It is recommended to aliquot the reconstituted (dissolved) protein into several discrete vials in order to avoid repeated freezing and thawing. Reconstituted protein can be stored at 4°C
PubChem LCSS	GHRP-6 Laboratory Chemical Safety Summary

Identifiers

CID	9919153
CAS	87616-84-0
InChI	InChI=1S/C46H56N12O6/c1-27(54-44(62)39(20-29-23-51-35-15-7-5-13-32(29)35)57-43(61)34(48)22-31-25-50-26-53-31)42(60)56-40(21-30-24-52-36-16-8-6-14-33(30)36)46(64)58-38(19-28-11-3-2-4-12-28)45(63)55-37(41(49)59)17-9-10-18-47/h2-8, 11-16, 23-27, 34, 37-40, 51-52H, 9-10, 17-22, 47-48H2, 1H3, (H2, 49, 59)(H, 50, 53)(H, 54, 62)(H, 55, 63)(H, 56, 60)(H, 57, 61)(H, 58, 64)/t27-, 34-, 37-, 38+, 39+, 40-/m0/s1
InChIKey	WZHKXNSOCOQYQX-FUAFALNISA-N
Isomeric SMILES	C[C@@H](C(=O)N[C@@H](CC1=CNC2=CC=CC=C21)C(=O)N[C@H](CC3=CC=CC=C3)C(=O)N[C@@H](CCCCN)C(=O)N)NC(=O)[C@@H](CC4=CNC5=CC=CC=C54)NC(=O)[C@H](CC6=CN=CN6)N
Canonical SMILES	CC(C(=O)NC(CC1=CNC2=CC=CC=C21)C(=O)NC(CC3=CC=CC=C3)C(=O)NC(CCCCN)C(=O)N)NC(=O)C(CC4=CNC5=CC=CC=C54)NC(=O)C(CC6=CN=CN6)N
IUPAC Name	(2S)-6-amino-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-amino-3-(1H-imidazol-5-yl)propanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]propanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-3-phenylpropanoyl]amino]hexanamide

Description

Description – GHRP-6

Growth Hormone Releasing Peptide 6 (GHRP-6) is a synthetic, 6-amino acid sequence, which is analogous to the naturally occurring protein met-enkephalin¹. GHRP-6 is a member of a classification of agents called growth hormone (GH) secretagogues that were collectively developed in an effort to artificially stimulate the release of GH². GHRP-6 is known to bind with the GH secretagogue receptor (ghrelin receptor) directly³, stimulating potent GH secretion and appetite in animal test subjects².The promotion of improved strength, increased muscle mass to body fat ratio, and the encouragement of good joint and connective tissue health has been observed in animal trials⁴. Studies in animal test subjects show that GHRP-6 stimulates Ghrelin, “the hunger hormone” through its ghrelin receptor, which in turn signals an increased production of growth hormone (GH) by acting at the level of the pituitary or hypothalamus through a specific receptor different from that of the endogenous Growth Hormone-Releasing Hormone GHRH.The four parts of the animal test subjects that demonstrate the role of GHRP-6 include the pituitary gland, central nervous system, liver, and stomach.

Product Comparison

Similar to other agents of GH release, GHRP-6 acts on the anterior pituitary gland⁵. In spite of having a similar site of action, GHRP-6 does not stimulate GH production using the same biochemical pathway as the popular GH secretagogue ‘sermorelin’ its analogues, like CJC-1295⁶. In light of this observation, it has been possible for researchers to administrate CJC-1295 and GHRP-6 concurrently in order to achieve an additive positive effect on GH release. A similar synergistic relationship has been documented with insulin, where much improved GH release was observed in animal trials following a concurrent dosing scheme⁷.

The GHRP Family

The GHRP family of proteins is distinct from growth hormone releasing hormones (GHRH or GHRF) in that they share no sequence relation and derive their function through action at a completely different receptor, the ghrelin receptor⁸. The GHRP family is unique in that they lack opiate activity, though they are analogues of species that bear this quality⁹.

Synonyms:

Growth Hormone Releasing Peptide-6; Growth hormone releasing hexapeptide; Somacrin; Somatocrinin-6; RP6;

Peer-Reviewed Sources:

McDowell RS, Elias KA, Stanley MS, Burdick DJ, Burnier JP, Chan KS, Fairbrother WJ, Hammonds RG, Ingle GS, Jacobsen NE (1995). Growth hormone secretagogues: characterization, efficacy, and minimal bioactive conformation. Proc Natl Acad Sci USA, 92:11165-11169. ↩︎
Fairhall, K. M., Mynett, A., & Robinson, I. C. A. F. (1995). Central effects of growth hormone-releasing hexapeptide (GHRP-6) on growth hormone release are inhibited by central somatostatin action. Journal of Endocrinology, 144(3), 555-560. ↩︎
Muccioli, G., Ghe, C., Ghigo, M. C., Papotti, M., Arvat, E., Boghen, M. F., Nilsson, H., Deghenghi, R., Ong, H., & Ghigo, E. (1998). Specific receptors for synthetic GH secretagogues in the human brain and pituitary gland. Journal of Endocrinology, 157(1), 99-106. ↩︎
Cella, S. G., Cerri, C. G., Daniel, S., Sibilia, V., Rigamonti, A., Cattaneo, L., Deghenghi, R., & Müller, E. E. (1996). Sixteen weeks of hexarelin therapy in aged dogs: effects on the somatotropic axis, muscle morphology, and bone metabolism. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 51(6), B439-B447. ↩︎
Mau, S. E., Witt, M. R., Bjerrum, O. J., Særmark, T., & Vilhardt, H. (1995). Growth hormone releasing hexapeptide (GHRP-6) activates the inositol (1, 4, 5)-trisphosphate/diacylglycerol pathway in rat anterior pituitary cells. Journal of Receptors and Signal Transduction,15(1-4), 311-323. ↩︎
Cordido, F., Penalva, A., Dieguez, C., & Casanueva, F. F. (1993). Massive growth hormone (GH) discharge in obese subjects after the combined administration of GH-releasing hormone and GHRP-6: evidence for a marked somatotroph secretory capability in obesity. The Journal of Clinical Endocrinology & Metabolism, 76(4), 819-823. ↩︎
Penalva, A., Carballo, A., Pombo, M., Casanueva, F. F., & Dieguez, C. (1993). Effect of growth hormone (GH)-releasing hormone (GHRH), atropine, pyridostigmine, or hypoglycemia on GHRP-6-induced GH secretion in man. The Journal of Clinical Endocrinology & Metabolism, 76(1), 168-171. ↩︎
Granado, M., Priego, T., Martín, A. I., Villanua, M. A., & López-Calderón, A. (2005). Anti-inflammatory effect of the ghrelin agonist growth hormone-releasing peptide-2 (GHRP-2) in arthritic rats. American Journal of Physiology-Endocrinology and Metabolism, 288(3), E486-E492. ↩︎
Casanueva, F. F., & Dieguez, C. (1999). Growth hormone secretagogues: physiological role and clinical utility. Trends in Endocrinology & Metabolism,10(1), 30-38. ↩︎

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