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Hexarelin – 2mg

Name: Hexarelin - 2mg - NuScience Peptides
Price: 19.99 USD
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$19.99

2 mg per vial

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Properties

Molecular Formula	C₄₇H₅₈N₁₂O₆
Molecular Weight	887.0
Monoisotopic Mass	886.46022862
Polar Area	301
Complexity	1600
XLogP	2.3
Heavy Atom Count	65
Hydrogen Bond Donor Count	11
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	23
Physical Appearance	Clear Liquid
Stability	Lyophilized protein is to be stored at -20°C. It is recommended to aliquot the reconstituted (dissolved) protein into several discrete vials in order to avoid repeated freezing and thawing. Reconstituted protein can be stored at 4°C
PubChem LCSS	Hexarelin Laboratory Chemical Safety Summary

Identifiers

CID	6918297
CAS	140703-51-1
InChI	InChI=1S/C47H58N12O6/c1-27-34(33-15-7-9-17-37(33)54-27)23-41(58-44(62)35(49)22-31-25-51-26-53-31)45(63)55-28(2)43(61)57-40(21-30-24-52-36-16-8-6-14-32(30)36)47(65)59-39(20-29-12-4-3-5-13-29)46(64)56-38(42(50)60)18-10-11-19-48/h3-9, 12-17, 24-26, 28, 35, 38-41, 52, 54H, 10-11, 18-23, 48-49H2, 1-2H3, (H2, 50, 60)(H, 51, 53)(H, 55, 63)(H, 56, 64)(H, 57, 61)(H, 58, 62)(H, 59, 65)/t28-, 35-, 38-, 39+, 40-, 41+/m0/s1
InChIKey	RVWNMGKSNGWLOL-GIIHNPQRSA-N
Isomeric SMILES	CC1=C(C2=CC=CC=C2N1)C[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CC3=CNC4=CC=CC=C43)C(=O)N[C@H](CC5=CC=CC=C5)C(=O)N[C@@H](CCCCN)C(=O)N)NC(=O)[C@H](CC6=CN=CN6)N
Canonical SMILES	CC1=C(C2=CC=CC=C2N1)CC(C(=O)NC(C)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)NC(CC5=CC=CC=C5)C(=O)NC(CCCCN)C(=O)N)NC(=O)C(CC6=CN=CN6)N
IUPAC Name	(2S)-6-amino-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-amino-3-(1H-imidazol-5-yl)propanoyl]amino]-3-(2-methyl-1H-indol-3-yl)propanoyl]amino]propanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-3-phenylpropanoyl]amino]hexanamide

Description

Description – Hexarelin

Hexarelin is a growth hormone (GH) releasing peptide (GHRP) analog comprised of 6 amino acid residues and having a methylated ‘Trp’ terminus in order to enhance structural stability and to prolong residence time in the bloodstream¹. Earning it the classification of a GH secretagogue (GHS), Hexarelin has been found to promote the production of GH by binding to the GHS (ghrelin) receptor within the pituitary gland and the hypothalamus².Hexarelin is reported to be a potent agent for the stimulation of GH production, which has been shown to be a promoter of enhanced muscle strength, increased muscle mass, improved joint health, quickened wound healing³, and damage protection threatened by cardiac dysfunction⁴. Animal testing has demonstrated that Hexarelin stimulates also significant secretion of IGF-1, PRL, ACTH, and cortisol⁵, while not to inducing appetite and gastric emptying, which is a property of other GHRP analogs⁶.

Product Comparison – Hexarelin

The regular administration of endogenous, synthetic GH has the potential to cause a parallel reduction of natural GH production as a result of modulation by somatostatin⁵, which may run counter to desired research outcomes. Rather than using synthetic GH to substitute production of the naturally occurring agent, it promotes natural GH production alongside normal, systemic production.

Hexarelin and GHRP-6 are noted to have similar capabilities in stimulating sustained GH release, but, as mentioned above, Hexarelin lacks GHRP-6’s appetite inducing properties⁶.

Synonyms:

Hexarelin Acetate, HEX, Examorelin

Peer-Reviewed Sources:

Torsello, A., Luoni, M., Schweiger, F., Grilli, R., Guidi, M., Bresciani, E., … & Locatelli, V. (1998). Novel hexarelin analogs stimulate feeding in the rat through a mechanism not involving growth hormone release. European journal of pharmacology, 360(2), 123-129.
Deghenghi, R., Cananzi, M. M., Torsello, A., Battisti, C., Muller, E. E., & Locatelli, V. (1994). GH-releasing activity of hexarelin, a new growth hormone releasing peptide, in infant and adult rats. Life sciences, 54(18), 1321-1328.
Acosta, J. B., Vera, D. C., Herrera, D. G. D. B., Nieto, G. E. G., Alba, J. S., Mola, E. L., & Castillo, M. V. (2011). Pharmaceutical Composition Containing GHRP-6 To Prevent And Eliminate Fibrosis And Other Pathological Deposits In Tissues. U.S. Patent Application 13/150,526.
Locatelli, V., Rossoni, G., Schweiger, F., Torsello, A., De Gennaro Colonna, V., Bernareggi, M., & Berti, F. (1999). Growth Hormone-Independent Cardioprotective Effects of Hexarelin in the Rat 1. Endocrinology, 140(9), 4024-4031.
Arvat, E., Maccario, M., Di Vito, L., Broglio, F., Benso, A., Gottero, C., & Ghigo, E. (2001). Endocrine activities of ghrelin, a natural growth hormone secretagogue (GHS), in humans: comparison and interactions with hexarelin, a nonnatural peptidyl GHS, and GH-releasing hormone 1. The Journal of Clinical Endocrinology & Metabolism, 86(3), 1169-1174.
Schmid, D. A., Held, K., Ising, M., Uhr, M., Weikel, J. C., & Steiger, A. (2005). Ghrelin stimulates appetite, imagination of food, GH, ACTH, and cortisol, but does not affect leptin in normal controls. Neuropsychopharmacology, 30(6), 1187-1192.

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