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Hexarelin – 2mg

Original price was: $29.99.Current price is: $19.99.

2 mg per vial

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Properties

Molecular Formula	C₄₇H₅₈N₁₂O₆
Molecular Weight	887.0
Monoisotopic Mass	886.46022862
Polar Area	301
Complexity	1600
XLogP	2.3
Heavy Atom Count	65
Hydrogen Bond Donor Count	11
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	23
Physical Appearance	Clear Liquid
Stability	Lyophilized protein is to be stored at -20°C. It is recommended to aliquot the reconstituted (dissolved) protein into several discrete vials in order to avoid repeated freezing and thawing. Reconstituted protein can be stored at 4°C
PubChem LCSS	Hexarelin Laboratory Chemical Safety Summary

Identifiers

CID	6918297
CAS	140703-51-1
InChI	InChI=1S/C47H58N12O6/c1-27-34(33-15-7-9-17-37(33)54-27)23-41(58-44(62)35(49)22-31-25-51-26-53-31)45(63)55-28(2)43(61)57-40(21-30-24-52-36-16-8-6-14-32(30)36)47(65)59-39(20-29-12-4-3-5-13-29)46(64)56-38(42(50)60)18-10-11-19-48/h3-9, 12-17, 24-26, 28, 35, 38-41, 52, 54H, 10-11, 18-23, 48-49H2, 1-2H3, (H2, 50, 60)(H, 51, 53)(H, 55, 63)(H, 56, 64)(H, 57, 61)(H, 58, 62)(H, 59, 65)/t28-, 35-, 38-, 39+, 40-, 41+/m0/s1
InChIKey	RVWNMGKSNGWLOL-GIIHNPQRSA-N
Isomeric SMILES	CC1=C(C2=CC=CC=C2N1)C[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CC3=CNC4=CC=CC=C43)C(=O)N[C@H](CC5=CC=CC=C5)C(=O)N[C@@H](CCCCN)C(=O)N)NC(=O)[C@H](CC6=CN=CN6)N
Canonical SMILES	CC1=C(C2=CC=CC=C2N1)CC(C(=O)NC(C)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)NC(CC5=CC=CC=C5)C(=O)NC(CCCCN)C(=O)N)NC(=O)C(CC6=CN=CN6)N
IUPAC Name	(2S)-6-amino-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-amino-3-(1H-imidazol-5-yl)propanoyl]amino]-3-(2-methyl-1H-indol-3-yl)propanoyl]amino]propanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-3-phenylpropanoyl]amino]hexanamide

Description

Hexarelin

This product is not intended for weight loss, human consumption, or veterinary use. It is sold for research purposes only. Please handle with care and follow all safety guidelines for the specific chemicals involved.

What Is Hexarelin Peptide?

Hexarelin peptide is a synthetic hexapeptide and potent growth hormone secretagogue (GHS) that has been extensively studied in rat models for its multifaceted physiological effects. Primarily recognized for stimulating growth hormone (GH) release, Hexarelin’s actions extend beyond endocrinology, encompassing cardioprotective and metabolic domains.In neonatal and adult rats, Hexarelin administration significantly elevates plasma GH levels. This effect is mediated through multiple mechanisms: direct pituitary stimulation, hypothalamic release of GH-releasing hormone (GHRH), and possibly other unidentified hypothalamic factors. Notably, in 10-day-old rats, repeated Hexarelin injections enhanced GH responses over time, indicating a sensitization effect.

Hexarelin Peptide and Cardioprotective Properties

Beyond its endocrine role, Hexarelin exhibits cardioprotective properties. In isolated rat hearts subjected to calcium paradox-induced injury, Hexarelin pre-treatment preserved ventricular function and reduced creatine kinase release, a marker of myocardial damage. citeturn0search8 This protection is attributed to Hexarelin’s direct action on cardiac tissues, independent of GH mediation. Further studies demonstrated Hexarelin’s ability to mitigate myocardial stunning in aged rats, highlighting its potential in age-related cardiac dysfunction.

Hexarelin in Metabolic and Mitochondrial Research

Hexarelin also influences metabolic pathways. In rats treated with cisplatin, a chemotherapeutic agent known to induce mitochondrial dysfunction, Hexarelin administration counteracted declines in mitochondrial biogenesis and mass in skeletal muscles. This suggests a protective role against chemotherapy-induced myopathy.

Peptide Hexarelin and Appetite Stimulation

Moreover, Hexarelin affects feeding behavior. In both young and old rats, subcutaneous administration of Hexarelin stimulated food intake in a dose-dependent manner. This orexigenic effect was sustained over prolonged treatment periods, indicating potential applications in conditions characterized by anorexia or cachexia.

Hexarelin Peptide — Therapeutic Potential and Future Research

In summary, Hexarelin’s diverse physiological effects in rat models underscore its therapeutic potential. Its ability to stimulate GH release, protect cardiac function, preserve mitochondrial integrity, and enhance appetite positions it as a promising candidate for further research in various clinical contexts.

Buy Hexarelin from NuScience Peptides to support your research into growth hormone secretagogues, cardioprotection, and metabolic pathways.

References

Ghigo, E., et al. “Mechanism of action of Hexarelin. I. Growth hormone-releasing activity in infant and adult rats.” Endocrinology, vol. 138, no. 2, 1997, pp. 693–698. https://pubmed.ncbi.nlm.nih.gov/8921832/
Rossoni, G., et al. “Hexarelin, a growth hormone secretagogue, protects the isolated rat heart from ventricular dysfunction produced by exposure to calcium-free medium.” Pharmacological Research, vol. 42, no. 2, 2000, pp. 129–136. https://pubmed.ncbi.nlm.nih.gov/10887041/
De Gennaro Colonna, V., et al. “Protectant activity of hexarelin or growth hormone against myocardial stunning in senescent rats.” Journal of Endocrinological Investigation, vol. 21, no. 10, 1998, pp. 655–659. https://pubmed.ncbi.nlm.nih.gov/9700988/
Agostini, S., et al. “Growth hormone secretagogues hexarelin and JMV2894 protect skeletal muscle from cisplatin-induced toxicity.” Scientific Reports, vol. 7, no. 1, 2017, article 13017. https://www.nature.com/articles/s41598-017-13504-y
Locatelli, V., et al. “Feeding behavior during long-term hexarelin administration in young and old rats.” Journal of Endocrinological Investigation, vol. 25, no. 10, 2002, pp. 870–875. https://link.springer.com/article/10.1007/BF03345618

NuScience Peptides has Hexarelin for sale strictly for research purposes only — not for human consumption..

Synonyms:

Hexarelin Acetate, HEX, Examorelin

ALL LITERATURE, INFORMATION, AND DATA, PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY.

Accurate research is our number one priority.

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We take pride in ensuring the utmost purity of our products. Every item we offer undergoes rigorous lab testing and is certified for the highest possible purity.

Frequently Asked Questions

1
What is Hexarelin peptide?

Hexarelin is a synthetic hexapeptide and potent growth hormone secretagogue (GHS) that has been extensively studied in rat models for its multifaceted physiological effects. It is primarily recognized for stimulating growth hormone (GH) release, with actions extending into cardioprotective and metabolic domains.

2
Does Hexarelin peptide have cardioprotective properties?

Yes. In isolated rat hearts subjected to calcium paradox-induced injury, Hexarelin pre-treatment preserved ventricular function and reduced creatine kinase release, a marker of myocardial damage. This protection is attributed to Hexarelin’s direct action on cardiac tissues, independent of GH mediation.

3
How does Hexarelin affect metabolism?

In rats treated with cisplatin, a chemotherapeutic agent known to induce mitochondrial dysfunction, Hexarelin administration counteracted declines in mitochondrial biogenesis and mass in skeletal muscles, suggesting a protective role against chemotherapy-induced myopathy.

4
Does Hexarelin stimulate appetite?

Yes. In both young and old rats, subcutaneous administration of Hexarelin stimulated food intake in a dose-dependent manner. This orexigenic effect was sustained over prolonged treatment periods, indicating potential applications in conditions characterized by anorexia or cachexia.

5
Where can I buy Hexarelin online?

You can buy Hexarelin online from NuScience Peptides in a 2mg research-grade format. All products are lab-tested for 99% purity with SAME-DAY and FREE U.S. shipping available.