Ipamorelin – 5mg


5 mg per vial

Rated 5.0 out of 5
5.0 out of 5 stars (based on 3 reviews)
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Rated 5.0 out of 5
October 8, 2023

I just go my first order of ipamorelin from NuScience. It arrived within a very short period of time. I got shipping and tracking information the same day. It arrived and the packaging was awesome, no chance of any damage. I would absolutely recommend them and I’ve used quite a few other companies and they are far and away one of the best to deal with!

Scott Weldon

Response from NuScience Peptides

I really appreciate that Scott! We truly try for a good customer experience all around. From fantastic pricing to superior customer service.


Rated 5.0 out of 5
August 11, 2023

One of my favorite products and works perfectly. Shipping was FAST.


OUTSTANDING customer service

Rated 5.0 out of 5
July 24, 2023

The customer service team went above and beyond to assist me with an issue I had with my order. They were prompt, and understanding, and resolved the problem in no time. I highly recommend NuScience!!!



Molecular Formula


Molecular Weight711.9
Monoisotopic Mass711.38566570
Polar Area240
Heavy Atom Count52
Hydrogen Bond Donor Count8
Hydrogen Bond Acceptor Count8
Rotatable Bond Count19
Physical AppearanceFine White Lyophilized Powder
StabilityLyophilized protein is to be stored at -20°C. It is recommended to aliquot the reconstituted (dissolved) protein into several discrete vials in order to avoid repeated freezing and thawing. Reconstituted protein can be stored at 4°C
PubChem LCSS

Ipamorelin Laboratory Chemical Safety Summary


InChIInChI=1S/C38H49N9O5/c1-38(2, 41)37(52)47-32(21-28-22-42-23-43-28)36(51)46-31(20-25-15-16-26-12-6-7-13-27(26)18-25)35(50)45-30(19-24-10-4-3-5-11-24)34(49)44-29(33(40)48)14-8-9-17-39/h3-7, 10-13, 15-16, 18, 22-23, 29-32H, 8-9, 14, 17, 19-21, 39, 41H2, 1-2H3, (H2, 40, 48)(H, 42, 43)(H, 44, 49)(H, 45, 50)(H, 46, 51)(H, 47, 52)/t29-, 30+, 31+, 32-/m0/s1
Isomeric SMILESCC(C)(C(=O)N[C@@H](CC1=CN=CN1)C(=O)N[C@H](CC2=CC3=CC=CC=C3C=C2)C(=O)N[C@H](CC4=CC=CC=C4)C(=O)N[C@@H](CCCCN)C(=O)N)N
IUPAC Name(2S)-6-amino-2-[[(2R)-2-[[(2R)-2-[[(2S)-2-[(2-amino-2-methylpropanoyl)amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-3-naphthalen-2-ylpropanoyl]amino]-3-phenylpropanoyl]amino]hexanamide


Ipamorelin is a synthetic 5 amino acid sequence developed as a small molecule, chemically stabilized analogy to the naturally occurring protein ghrelin1. Ipamorelin is a member of a classification of agents called growth hormone (GH) secretagogues that were collectively developed in an effort to artificially stimulate the release of GH2.

Ipamorelin is known to bind with the GH secretagogue receptor (ghrelin receptor) directly3, stimulating potent GH secretion in animal test subjects. Unlike its native analogy, ghrelin, Ipamorelin is a non-lipogenic peptide and suppresses somatostatin-induced regulation of GH production4.

The promotion of improved strength, increased muscle mass to body fat ratio, and the encouragement of good joint and connective tissue health has been observed in animal trials where high levels of GH release has been induced5. Ipamorelin, specifically, has been shown to also have a positive effect on bone growth in rats6.

Product Comparison

Similar to other agents of GH release, Ipamorelin acts on the anterior pituitary gland1. Ipamorelin’s mechanism of action is very similar to GHRP-2, being a ‘true’ GH secretagogue, reflecting its ability to stimulate the natural, body-mediated production of GH rather than introducing exogenous, synthetic agents to a physiological system.

Like GHRP-6 and GHRP-2, Ipamorelin acts synergistically with growth hormone-releasing hormone (GHRH) or any of its analogies, like Sermorelin or CJC-1295, to achieve a very potent release of GH7. In light of this observation, it has been possible for researchers to administrate GHRH’s or GHRH analogies with Ipamorelin concurrently in order to achieve an additive positive effect on GH release.

Unlike GHRP-6 and GHRP-2, which are known to release prolactin and cortisol along with GH, Ipamorelin is specific in its release of GH through a broad spectrum of doses1.

The GHRP Family

The GHRP family of proteins is distinct from GHRH’s (or GHRFs) in that they share no sequence relation and derive their function through action at a completely different receptor, the ghrelin receptor8. The GHRP family is unique in that they lack opiate activity, though they are analogues of species that bear this quality2.


Ipamorelin Acetate, IPAM, NNC-26-0161

Peer-Reviewed Sources:

  1. Raun, K., Hansen, B. S., Johansen, N. L., Thogersen, H., Madsen, K., Ankersen, M., & Andersen, P. H. (1998). Ipamorelin, the first selective growth hormone secretagogue. European Journal of Endocrinology, 139(5), 552-561.
  2. Casanueva, F. F., & Dieguez, C. (1999). Growth hormone secretagogues: physiological role and clinical utility. Trends in Endocrinology & Metabolism,10(1), 30-38.
  3. Holst, B., Cygankiewicz, A., Jensen, T. H., Ankersen, M., & Schwartz, T. W. (2003). High constitutive signaling of the ghrelin receptor—identification of a potent inverse agonist. Molecular Endocrinology, 17(11), 2201-2210.
  4. Jiménez Reina, L., Cañete, R., De La Torre, M. J., & Bernal, G. (2002). Influence of chronic treatment with the growth hormone secretagogue Ipamorelin, in young female rats somatotroph response in vitro.
  5. Jenkins, P. J. (1999). Growth hormone and exercise. Clinical endocrinology, 50(6), 683-689.
  6. Johansen, P. B., Nowak, J., Skjærbæk, C., Flyvbjerg, A., Andreassen, T. T., Wilken, M., & Ørskov, H. (1999). Ipamorelin, a new growth-hormone-releasing peptide, induces longitudinal bone growth in rats. Growth Hormone & IGF Research, 9(2), 106-113.
  7. Gobburu, J. V., Agersø, H., Jusko, W. J., & Ynddal, L. (1999). Pharmacokinetic-pharmacodynamic modeling of ipamorelin, a growth hormone releasing peptide, in human volunteers. Pharmaceutical research, 16(9), 1412-1416.
  8. Granado, M., Priego, T., Martín, A. I., Villanua, M. A., & López-Calderón, A. (2005). Anti-inflammatory effect of the ghrelin agonist growth hormone-releasing peptide-2 (GHRP-2) in arthritic rats. American Journal of Physiology-Endocrinology and Metabolism, 288(3), E486-E492.


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