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Melanotan II – 10mg

Original price was: $34.99.Current price is: $29.99.

10 mg per vial

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Properties

Molecular Formula	C₅₀H₆₉N₁₅O₉
Molecular Weight	1024.2
Monoisotopic Mass	1023.54026884
Polar Area	385
Complexity	1950
XLogP	0
Heavy Atom Count	74
Hydrogen Bond Donor Count	13
Hydrogen Bond Acceptor Count	11
Rotatable Bond Count	17
Physical Appearance	Fine White Lyophilized Powder
Stability	Lyophilized protein is to be stored at -20°C. It is recommended to aliquot the reconstituted (dissolved) protein into several discrete vials in order to avoid repeated freezing and thawing. Reconstituted protein can be stored at 4°C
PubChem LCSS	Melanotan II Laboratory Chemical Safety Summary

Identifiers

CID	92432
CAS	121062-08-6
InChI	InChI=1S/C50H69N15O9/c1-3-4-16-36(59-29(2)66)44(69)65-41-25-42(67)55-20-11-10-18-35(43(51)68)60-47(72)39(23-31-26-57-34-17-9-8-15-33(31)34)63-45(70)37(19-12-21-56-50(52)53)61-46(71)38(22-30-13-6-5-7-14-30)62-48(73)40(64-49(41)74)24-32-27-54-28-58-32/h5-9, 13-15, 17, 26-28, 35-41, 57H, 3-4, 10-12, 16, 18-25H2, 1-2H3, (H2, 51, 68)(H, 54, 58)(H, 55, 67)(H, 59, 66)(H, 60, 72)(H, 61, 71)(H, 62, 73)(H, 63, 70)(H, 64, 74)(H, 65, 69)(H4, 52, 53, 56)/t35-, 36-, 37-, 38+, 39-, 40-, 41-/m0/s1
InChIKey	JDKLPDJLXHXHNV-MFVUMRCOSA-N
Isomeric SMILES	CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)CC2=CN=CN2)CC3=CC=CC=C3)CCCN=C(N)N)CC4=CNC5=CC=CC=C54)C(=O)N)NC(=O)C
Canonical SMILES	CCCCC(C(=O)NC1CC(=O)NCCCCC(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)CC2=CN=CN2)CC3=CC=CC=C3)CCCN=C(N)N)CC4=CNC5=CC=CC=C54)C(=O)N)NC(=O)C
IUPAC Name	(3S, 6S, 9R, 12S, 15S, 23S)-15-[[(2S)-2-acetamidohexanoyl]amino]-9-benzyl-6-[3-(diaminomethylideneamino)propyl]-12-(1H-imidazol-5-ylmethyl)-3-(1H-indol-3-ylmethyl)-2, 5, 8, 11, 14, 17-hexaoxo-1, 4, 7, 10, 13, 18-hexazacyclotricosane-23-carboxamide

Description

Melanotan II

This product is not intended for weight loss, human consumption, or veterinary use. It is sold for research purposes only. Please handle with care and follow all safety guidelines for the specific chemicals involved.

Melanotan II 10 mg (MT-II)/Melanotan 2 is a synthetic analog of α-melanocyte-stimulating hormone and a potent non-selective agonist of melanocortin receptors (MCRs). This melanotan II peptide is widely used in preclinical research to study energy homeostasis, feeding behavior, thermoregulation, and neuroendocrine functions in rodent models.

One of the primary applications of melanotan II peptide in rodent research is its anorexigenic effect. Central administration of MT-II significantly reduces food intake and body weight in rats, implicating melanocortin-3 and -4 receptors (MC3R and MC4R) in the regulation of appetite and energy balance. These effects are observed when MT-II is administered into various brain regions, including the forebrain and hindbrain ventricles, suggesting a distributed control of feeding behavior via MCRs.

In addition, Melanotan II 10 mg has been shown to influence thermoregulation. Peripheral administration induces hypothermia in mice by activating mast cells and stimulating histamine receptors, highlighting a mechanism independent of canonical melanocortin receptors. This demonstrates the complex interplay between melanotan 2 peptide and various physiological systems beyond the central nervous system.

Moreover, MT-II has demonstrated potential in enhancing recovery following neural injury. In a rat model of sciatic nerve crush injury, administration of melanotan II peptide significantly improved sensory function recovery, suggesting a role in promoting neural regeneration.

Melanotan II 10 mg also affects sexual behavior in rodents. Studies show MT-II enhances proceptive sexual behaviors in female rats, indicating its influence on sexual motivation and behavior through central melanocortin pathways.

Additionally, MT-II has been implicated in modulating reward-related behaviors. Microinjection of melanotan 2 peptide into the nucleus accumbens of rats reduced motivation to obtain food without affecting actual intake, supporting its use as a research tool in appetite and behavior studies.

In summary, Melanotan II 10 mg serves as a valuable tool for investigating melanocortin system pathways in rodent research. Its multifaceted effects on feeding, thermoregulation, neural recovery, sexual behavior, and motivation underscore the importance of this melanotan II peptide in preclinical studies.

References:

Raposinho, P. D., White, R. B., & Aubert, M. L. (2003). The melanocortin agonist melanotan-II reduces the orexigenic and adipogenic effects of neuropeptide Y (NPY) but does not affect the NPY-driven suppressive effects on the gonadotropic and somatotropic axes in the male rat. Journal of Neuroendocrinology, 15(2), 173–181.
Jain, S., Panyutin, A., Liu, N., Xiao, C., Pinol, R. A., & Pundir, P. (2018). Melanotan II causes hypothermia in mice by activation of mast cells and stimulation of histamine 1 receptors. American Journal of Physiology-Endocrinology and Metabolism, 315(2), E357–E366.
The potent melanocortin receptor agonist melanotan-II promotes recovery of sensory function following sciatic nerve injury in rats. European Journal of Pharmacology, 2002.
The melanocortin agonist, melanotan II, enhances proceptive sexual behaviors in the female rat. Pharmacology Biochemistry and Behavior, 2006.
Melanocortin receptor agonist melanotan-II microinjected in the nucleus accumbens reduces motivation to obtain food in rats. Physiology & Behavior, 2022.

ALL LITERATURE, INFORMATION, AND DATA, PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY.

Accurate research is our number one priority.

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Frequently Asked Questions

Everything you need to know about Melanotan II 10 mg research peptide

1
What distinguishes Melanotan II 10 mg from other melanocortin peptides?

Melanotan II 10 mg is a cyclic melanotan II peptide with high affinity for multiple melanocortin receptors (MC1R, MC3R, MC4R, and MC5R). Unlike linear α-MSH analogs, its structure confers increased receptor binding stability, making it a preferred research compound for studying complex melanocortin signaling pathways.

2
Why is Melanotan II peptide commonly used in appetite and energy balance studies?

The melanotan II peptide robustly activates MC3R and MC4R receptors, which are central regulators of appetite suppression and energy expenditure. In rodent models, this makes Melanotan II 10 mg particularly valuable for dissecting hypothalamic control of feeding behavior and metabolic regulation.

3
Does Melanotan II 10 mg interact with systems outside the central nervous system?

Yes. Research demonstrates that Melanotan II 10 mg can influence peripheral physiological systems, including thermoregulation and immune-mediated responses. Its ability to induce hypothermia through mast cell activation highlights non-canonical pathways independent of classical melanocortin receptor signaling.

4
What role does Melanotan II peptide play in neuroregeneration research?

Preclinical studies indicate that melanotan II peptide may support neural recovery following injury by modulating inflammatory signaling and neurotrophic pathways. This makes Melanotan II 10 mg a useful tool in experimental models focused on nerve regeneration and sensory function restoration.

5
How is Melanotan II 10 mg applied in behavioral neuroscience research?

Melanotan II 10 mg is frequently used to study motivation, reward processing, and sexual behavior in rodent models. Its action within regions such as the nucleus accumbens allows researchers to isolate melanocortin-mediated effects on goal-directed behavior without directly altering caloric intake.

6
Is Melanotan II peptide suitable for chronic research protocols?

Yes, but stability considerations are critical. While melanotan II peptide is structurally more stable than many linear peptides, long-term studies typically require controlled storage, precise reconstitution, and avoidance of repeated freeze–thaw cycles to maintain experimental consistency.

7
What purity and verification standards apply to Melanotan II 10 mg?

Each batch of Melanotan II 10 mg is supplied with third-party COA documentation, including HPLC purity analysis and molecular weight confirmation. This ensures reproducibility and reliability in high-level preclinical research environments.

8
Can Melanotan II 10 mg be combined with other peptides in research studies?

Yes. In experimental settings, melanotan II peptide is sometimes studied alongside other neuropeptides or metabolic regulators to evaluate receptor crosstalk, synergistic signaling, or pathway specificity. Such combinations are strictly limited to laboratory research protocols.

9
How should Melanotan II 10 mg be stored for optimal research integrity?

Lyophilized Melanotan II 10 mg should be stored at −20°C or below in a dry, light-protected environment. Once reconstituted, aliquoting and freezing are recommended to preserve peptide integrity across experimental timelines.

10
Is Melanotan II 10 mg approved for human or veterinary use?

No. Melanotan II 10 mg is supplied strictly for laboratory and analytical research purposes only. It is not approved for human consumption, clinical use, or veterinary applications.