MOTS-c 10mg Peptide

Original price was: $64.99.Current price is: $49.99.

10 mg per vial

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Molecular Formula


Molecular Weight 2174.6 g/mol
Monoisotopic Mass 2173.1077409 g/mol
Polar Area 890A2
Heavy Atom Count
Hydrogen Bond Donor Count 31
Hydrogen Bond Acceptor Count 29
Rotatable Bond Count 73
Physical Appearance Fine White Lyophilized Powder
StabilityLyophilized protein is to be stored at -20°C. It is recommended to aliquot the reconstituted (dissolved) protein into several discrete vials in order to avoid repeated freezing and thawing. Reconstituted protein can be stored at 4°C
PubChem LCSS

PubChem MOTS-c


Isomeric SMILES CC[C@H](C)[C@@H](C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC2=CC=C(C=C2)O)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)NC(=O)[C@H](CC4=CC=C(C=C4)O)NC(=O)CNC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CC5=CNC6=CC=CC=C65)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCSC)N
IUPAC Name (4S)-4-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-methylsulfanylbutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-oxopentanoyl]amino]-5-[[(2S)-1-[[2-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(1S)-4-carbamimidamido-1-carboxybutyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-5-oxopentanoic acid


NuScience Peptides sells research products only, they are not for human consumption.

MOTS-c Description

MOTS-c (mitochondrial open reading frame of the 12S rRNA-c) is a recently discovered peptide encoded by the mitochondrial genome. It has gained significant attention for its potential role in metabolic regulation, aging, and disease prevention. Here’s an overview of MOTS-c for research purposes, supported by PubMed references:

Key Features and Mechanism of Action

  1. Mitochondrial Origin: Unlike most peptides, which are encoded by nuclear DNA, MOTS-c is encoded by the mitochondrial genome, specifically within the 12S rRNA region. This unique origin links its function closely to mitochondrial activity and energy regulation.
  2. Metabolic Regulation: MOTS-c plays a critical role in regulating metabolic homeostasis. It has been shown to enhance glucose metabolism and insulin sensitivity, making it a potential therapeutic candidate for metabolic diseases such as type 2 diabetes.
  3. Stress Response: MOTS-c can modulate the cellular stress response, particularly oxidative stress, by enhancing antioxidant defenses and improving mitochondrial function. This contributes to its protective effects in various cell types and tissues.
  4. Exercise Mimetic: Research suggests that MOTS-c acts as an exercise mimetic, promoting similar metabolic benefits to those observed with physical exercise, such as improved muscle insulin sensitivity and increased energy expenditure.

Research Applications

  1. Metabolic Diseases: The primary focus of MOTS-c research is its potential to treat metabolic disorders. Studies have demonstrated its effectiveness in improving insulin sensitivity, lowering blood glucose levels, and reducing obesity in animal models.
  2. Aging and Longevity: MOTS-c is being explored for its role in aging and longevity. Its ability to enhance mitochondrial function and reduce oxidative stress may contribute to healthier aging and extended lifespan.
  3. Muscle Function and Exercise: Given its exercise-mimetic properties, MOTS-c is of interest for improving muscle function and endurance. It may have applications in treating muscle-wasting conditions and enhancing physical performance.
  4. Cardiovascular Health: Emerging research indicates that MOTS-c may have cardioprotective effects, potentially benefiting conditions such as hypertension and atherosclerosis through its metabolic and anti-inflammatory actions.

Preclinical and Clinical Research

  1. Animal Studies: MOTS-c has been shown to improve metabolic parameters in various animal models. For instance, studies in mice have demonstrated its ability to enhance insulin sensitivity, reduce body weight, and protect against diet-induced obesity .
  2. Cellular Studies: In vitro studies have elucidated the mechanisms by which MOTS-c exerts its effects, including the activation of AMPK (AMP-activated protein kinase) and modulation of the insulin signaling pathway .
  3. Human Studies: Preliminary human studies suggest that MOTS-c levels are associated with metabolic health. Clinical trials are underway to further investigate its potential therapeutic benefits in humans .


  1. Lee, C., Zeng, J., Drew, B. G., Sallam, T., Martin-Montalvo, A., Wan, J., … & Cohen, P. (2015). The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metabolism, 21(3), 443-454. DOI: 10.1016/j.cmet.2015.02.009.
  2. Kim, K. H., Son, J. M., Benayoun, B. A., & Lee, C. (2018). The mitochondrial-encoded peptide MOTS-c translocates to the nucleus to regulate nuclear gene expression in response to metabolic stress. Cell Metabolism, 28(4), 516-524.e7. DOI: 10.1016/j.cmet.2018.06.008.
  3. Reynolds, J. C., Lai, R. W., Woodhead, J. S., Joly, J. H., Mitchell, C. J., Cameron-Smith, D., … & Levinger, I. (2021). MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis. Nature Communications, 12(1), 470. DOI: 10.1038/s41467-020-20790-0.
  4. Lu, H., Wei, M., Zhai, Y., Li, Q., Ye, G., & Qiu, Z. (2019). MOTS-c peptide regulates adipose homeostasis to prevent ovariectomy-induced metabolic dysfunction. Journal of Molecular Endocrinology, 63(3), 177-188. DOI: 10.1530/JME-19-0031.
  5. Ramanjaneya, M., Bettahi, I., Jerobin, J., Alreshaid, R., Almulla, H., Siveen, K. S., … & Abou-Samra, A. B. (2019). Mitochondrial peptide MOTS-c in obesity: Evidence from obese subjects and obese rodent models. Diabetes, Obesity and Metabolism, 21(1), 1835-1846. DOI: 10.1111/dom.13732.
  6. Reynolds, J. C., Mitchell, C. J., & Levinger, I. (2020). The role of MOTS-c in regulating physical performance and muscle function: Evidence from animal and human studies. Frontiers in Endocrinology, 11, 511. DOI: 10.3389/fendo.2020.00511.


MOTS-c is a mitochondrial-derived peptide with significant potential in metabolic research, particularly for its effects on glucose metabolism, obesity, aging, and muscle function. Its unique origin and multifunctional roles make it an exciting target for ongoing and future studies aimed at understanding and harnessing its therapeutic potential.

NuScience Peptides sells research products only, they are not for human consumption.


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