NAD+ – 500mg

Original price was: $129.00.Current price is: $79.99.


Out of stock



Molecular Formula


Molecular Weight 663.4
Monoisotopic Mass 663.10912256
Polar Area 321
XLogP -6
Heavy Atom Count 44
Hydrogen Bond Donor Count 7
Hydrogen Bond Acceptor Count 18
Rotatable Bond Count 11
Physical Appearance Fine White Lyophilized Powder
StabilityLyophilized protein is to be stored at -20°C. It is recommended to aliquot the reconstituted (dissolved) protein into several discrete vials in order to avoid repeated freezing and thawing. Reconstituted protein can be stored at 4°C
PubChem LCSS

Laboratory Chemical Safety Summary (LCSS) Datasheet


Isomeric SMILES C1=CC(=C[N+](=C1)[C@H]2[C@@H]([C@@H]([C@H](O2)COP(=O)([O-])OP(=O)(O)OC[C@@H]3[C@H]([C@H]([C@@H](O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N
Canonical SMILES C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)([O-])OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N
IUPAC Name [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4R,5R)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate


NuScience Peptides sells research products only, they are not for human consumption.

Description – NAD+

Nicotinamide adenine dinucleotide (NAD+) was discovered more than a century ago by Sir Arthur Harden as a low molecular weight substance present in a boiled yeast extract, which could stimulate fermentation and alcohol production in vitro. Subsequent studies over the next several decades determined that the structure of NAD comprised two covalently joined mononucleotides (nicotinamide mononucleotide or NMN, and AMP), and identified the keystone function of NAD+ and NADH as enzyme cofactors mediating hydrogen transfer in oxidative or reductive metabolic reactions.From single-cell organisms like bacteria to sophisticated multicellular ones like primates, NAD is one of the most abundant and crucial molecules. Basically, without NAD, we would be on the fast track to death. The molecule is a linchpin to the function of the generators of cells, mitochondria. NAD+ not only helps convert food to energy but also plays a crucial role in maintaining DNA integrity and ensures proper cellular function to protect our bodies from aging and disease.

How does NAD+ work?

NAD works as a shuttle bus, transferring electrons from one molecule to another within cells to carry out all sorts of reactions and processes. With its molecular counterpart, NADH, this vital molecule participates in various metabolic reactions that generate our cell’s energy. Without sufficient NAD levels, our cells wouldn’t be able to generate any energy to survive and carry out their functions. Other functions of NAD include regulating our circadian rhythm, which controls our body’s sleep/wake cycle.

A need for NAD+ in muscle development, homeostasis, and aging.

In a review study, researchers discuss the recent data that document conserved roles for NAD+ in skeletal muscle development, regeneration, aging, and disease as well as interventions targeting skeletal muscle and affecting NAD that suggest promising therapeutic benefits. The researchers also highlight gaps in our knowledge and propose avenues of future investigation to better understand why and how NAD regulates skeletal muscle biology.

NAD + in Brain Aging and Neurodegenerative Disorders.

NAD is a pivotal metabolite involved in cellular bioenergetics, genomic stability, mitochondrial homeostasis, adaptive stress responses, and cell survival. Multiple NAD-dependent enzymes are involved in synaptic plasticity and neuronal stress resistance. Here, we review emerging findings that reveal key roles for NAD+ and related metabolites in the adaptation of neurons to a wide range of physiological stressors and in counteracting processes in neurodegenerative diseases, such as those occurring in Alzheimer’s, Parkinson’s, and Huntington diseases, and amyotrophic lateral sclerosis. Advances in understanding the molecular and cellular mechanisms of NAD-based neuronal resilience will lead to novel approaches for facilitating healthy brain aging and for the treatment of a range of neurological disorders.

Reduces cancer risk

NAD plays a critical role in cellular health and the benefits of NAD+ may include the prevention, treatment, and arrest of certain types of cancer. But researchers have recently shown that NAD’s role in cancer may be more complicated, and the energy boost it gives to cells could even enhance the uncontrolled cell growth that characterizes cancer. More research is required to determine how NAD can target and destroy cancer cells and how it might encourage their growth under certain circumstances.

NuScience Peptides sells research products only, they are not for human consumption.


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