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|Heavy Atom Count||44|
|Hydrogen Bond Donor Count||7|
|Hydrogen Bond Acceptor Count||18|
|Rotatable Bond Count||11|
|Physical Appearance||Fine White Lyophilized Powder|
|Stability||Lyophilized protein is to be stored at -20°C. It is recommended to aliquot the reconstituted (dissolved) protein into several discrete vials in order to avoid repeated freezing and thawing. Reconstituted protein can be stored at 4°C|
|IUPAC Name||[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4R,5R)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate|
Description – NAD+
How does NAD+ work?
NAD works as a shuttle bus, transferring electrons from one molecule to another within cells to carry out all sorts of reactions and processes. With its molecular counterpart, NADH, this vital molecule participates in various metabolic reactions that generate our cell’s energy. Without sufficient NAD levels, our cells wouldn’t be able to generate any energy to survive and carry out their functions. Other functions of NAD include regulating our circadian rhythm, which controls our body’s sleep/wake cycle.
A need for NAD+ in muscle development, homeostasis, and aging.
In a review study, researchers discuss the recent data that document conserved roles for NAD+ in skeletal muscle development, regeneration, aging, and disease as well as interventions targeting skeletal muscle and affecting NAD that suggest promising therapeutic benefits. The researchers also highlight gaps in our knowledge and propose avenues of future investigation to better understand why and how NAD regulates skeletal muscle biology.
NAD + in Brain Aging and Neurodegenerative Disorders.
NAD is a pivotal metabolite involved in cellular bioenergetics, genomic stability, mitochondrial homeostasis, adaptive stress responses, and cell survival. Multiple NAD-dependent enzymes are involved in synaptic plasticity and neuronal stress resistance. Here, we review emerging findings that reveal key roles for NAD+ and related metabolites in the adaptation of neurons to a wide range of physiological stressors and in counteracting processes in neurodegenerative diseases, such as those occurring in Alzheimer’s, Parkinson’s, and Huntington diseases, and amyotrophic lateral sclerosis. Advances in understanding the molecular and cellular mechanisms of NAD-based neuronal resilience will lead to novel approaches for facilitating healthy brain aging and for the treatment of a range of neurological disorders.
Reduces cancer risk
NAD plays a critical role in cellular health and the benefits of NAD+ may include the prevention, treatment, and arrest of certain types of cancer. But researchers have recently shown that NAD’s role in cancer may be more complicated, and the energy boost it gives to cells could even enhance the uncontrolled cell growth that characterizes cancer. More research is required to determine how NAD can target and destroy cancer cells and how it might encourage their growth under certain circumstances.
ALL LITERATURE, INFORMATION, AND DATA, PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY.