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|Physical Appearance||Fine White Lyophilized Powder|
|Stability||Lyophilized protein is to be stored at -20°C. It is recommended to aliquot the reconstituted (dissolved) protein into several discrete vials in order to avoid repeated freezing and thawing. Reconstituted protein can be stored at 4°C.|
Though IGF-1 and PEG-MGF are very similar in origin and in (partial) structure, the two agents have very different mechanisms of action. Researchers have expressed that these two agents show great synergy and have observed enhanced rates in muscle growth while both IGF-1 LR3 (or IGF-1 DES) and MGF have been administrated together in animal subjects.
PEG-MGF is much more stable than unprotected MGF, which infers a much longer residence time in the bloodstream. Preference for MGF’s ‘burst’ profile or PEG-MGF’s sustained profile of activity must be determined by the research intent.
Pegylated MGF, PEG IGF-1 Ec; Pegylated MGF Splice Variant of IGF-;
- Hill, M., & Goldspink, G. (2003). Expression and Splicing of the Insulin‐Like Growth Factor Gene in Rodent Muscle is Associated with Muscle Satellite (stem) Cell Activation following Local Tissue Damage. The Journal of physiology, 549(2), 409-418. ↩︎
- Matheny Jr, R. W., Nindl, B. C., & Adamo, M. L. (2010). Minireview: Mechano-growth factor: a putative product of IGF-I gene expression involved in tissue repair and regeneration. Endocrinology, 151(3), 865-875. ↩︎
- Iida, K., Itoh, E., Kim, D. S., Del Rincon, J. P., Coschigano, K. T., Kopchick, J. J., & Thorner, M. O. (2004). Muscle mechano growth factor is preferentially induced by growth hormone in growth hormone‐deficient lit/lit mice. The Journal of physiology, 560(2), 341-349. ↩︎
- Goldspink, G. (1999). Changes in muscle mass and phenotype and the expression of autocrine and systemic growth factors by muscle in response to stretch and overload. Journal of anatomy, 194(03), 323-334. ↩︎
- Quesada, A., Micevych, P., & Handforth, A. (2009). C-terminal mechano growth factor protects dopamine neurons: a novel peptide that induces heme oxygenase-1. Experimental neurology, 220(2), 255-266. ↩︎
- Barton-Davis, E. R., Shoturma, D. I., Musaro, A., Rosenthal, N., & Sweeney, H. L. (1998). Viral mediated expression of insulin-like growth factor I blocks the aging-related loss of skeletal muscle function. Proceedings of the National Academy of Sciences, 95(26), 15603-15607. ↩︎
- Carpenter, V., Matthews, K., Devlin, G., Stuart, S., Jensen, J., Conaglen, J., & McMahon, C. (2008). Mechano-growth factor reduces loss of cardiac function in acute myocardial infarction. Heart, lung and circulation, 17(1), 33-39. ↩︎
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