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PEG-MGF – 2mg

Name: PEG-MGF - 2mg - NuScience Peptides
Price: 27.99 USD
Availability: InStock

$27.99

2 mg per vial

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Properties

Molecular Formula	C₁₂₁H₂₀₀N₄₂O₃₉
Molecular Weight	2888.16
Monoisotopic Mass	12264.9
Polar Area	n/a
Complexity	n/a
XLogP	n/a
Heavy Atom Count	n/a
Hydrogen Bond Donor Count	n/a
Hydrogen Bond Acceptor Count	n/a
Rotatable Bond Count	n/a
Physical Appearance	Fine White Lyophilized Powder
Stability	Lyophilized protein is to be stored at -20°C. It is recommended to aliquot the reconstituted (dissolved) protein into several discrete vials in order to avoid repeated freezing and thawing. Reconstituted protein can be stored at 4°C.
PubChem LCSS	n/a

Identifiers

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IUPAC Name

Description

Description PEG-MGF

Polyethylene Glycol (PEG) Mechano Growth Factor (MGF) is an isoform of Insulin Like Growth Factor 1 (IGF-1) comprised of 24 amino acid residues that is stabilized by a biocompatible polymer coating (PEG). The C-terminal residue sequence of MGF infers the characteristics that make this peptide unique from IGF-1¹.A natural form of MGF is expressed in muscle tissues in response to the overburdening or damage of these cells². MGF has been found to induce the stimulation of repair, regrowth, and the formation of new cells in response to stress³. This process is called hypertrophy (or hyperplasia) and is crucial in the gaining of muscle mass.The natural production of MGF stimulates the recruitment of undamaged cells to give rise to new muscle tissues, while a liver-derived variant of this agent (IGF-1Ea) initiates the upregulation – or positive feedback control – of protein synthesis⁴. Through these biochemical pathways, MGF is thought to be the primary mechanism by which the body naturally produces new muscle tissue.Animal studies have shown PEG-MGF as an active neuroprotective agent⁵ and a promoter of conserved skeletal health⁶. Also, reinforcing its functionality as an agent of muscle tissue repair, PEG-MGF has been found to be active in coordinating the repair of heart muscle tissue following myocardial infarction (heart attack)⁷. One study found that human mesenchymal stem cells migrated towards PEG-MGF, highlighting its potential role in cardiac tissue repair. In neonatal rat ventricular stem cells, apoptosis was inhibited with exposure to MGF.

Product Comparison

Though IGF-1 and PEG-MGF are very similar in origin and in (partial) structure, the two agents have very different mechanisms of action. Researchers have expressed that these two agents show great synergy and have observed enhanced rates in muscle growth while both IGF-1 LR3 (or IGF-1 DES) and MGF have been administrated together in animal subjects.

PEG-MGF is much more stable than unprotected MGF, which infers a much longer residence time in the bloodstream. Preference for MGF’s ‘burst’ profile or PEG-MGF’s sustained profile of activity must be determined by the research intent.

Synonyms:

Pegylated MGF, PEG IGF-1 Ec; Pegylated MGF Splice Variant of IGF-;

Peer-Reviewed Sources:

Hill, M., & Goldspink, G. (2003). Expression and Splicing of the Insulin‐Like Growth Factor Gene in Rodent Muscle is Associated with Muscle Satellite (stem) Cell Activation following Local Tissue Damage. The Journal of physiology, 549(2), 409-418. ↩︎
Matheny Jr, R. W., Nindl, B. C., & Adamo, M. L. (2010). Minireview: Mechano-growth factor: a putative product of IGF-I gene expression involved in tissue repair and regeneration. Endocrinology, 151(3), 865-875. ↩︎
Iida, K., Itoh, E., Kim, D. S., Del Rincon, J. P., Coschigano, K. T., Kopchick, J. J., & Thorner, M. O. (2004). Muscle mechano growth factor is preferentially induced by growth hormone in growth hormone‐deficient lit/lit mice. The Journal of physiology, 560(2), 341-349. ↩︎
Goldspink, G. (1999). Changes in muscle mass and phenotype and the expression of autocrine and systemic growth factors by muscle in response to stretch and overload. Journal of anatomy, 194(03), 323-334. ↩︎
Quesada, A., Micevych, P., & Handforth, A. (2009). C-terminal mechano growth factor protects dopamine neurons: a novel peptide that induces heme oxygenase-1. Experimental neurology, 220(2), 255-266. ↩︎
Barton-Davis, E. R., Shoturma, D. I., Musaro, A., Rosenthal, N., & Sweeney, H. L. (1998). Viral mediated expression of insulin-like growth factor I blocks the aging-related loss of skeletal muscle function. Proceedings of the National Academy of Sciences, 95(26), 15603-15607. ↩︎
Carpenter, V., Matthews, K., Devlin, G., Stuart, S., Jensen, J., Conaglen, J., & McMahon, C. (2008). Mechano-growth factor reduces loss of cardiac function in acute myocardial infarction. Heart, lung and circulation, 17(1), 33-39. ↩︎

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