Semaglutide 2mg | 5mg | 10mg


2 mg per vial | 5 mg per vial | 10mg per vial

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Molecular Formula


Molecular Weight 4114
Monoisotopic Mass 4111.1153770
Polar Area 1650
XLogP -5.8
Heavy Atom Count 291
Hydrogen Bond Donor Count 57
Hydrogen Bond Acceptor Count 63
Rotatable Bond Count 151
Physical Appearance Fine White Lyophilized Powder
StabilityLyophilized protein is to be stored at -20°C. It is recommended to aliquot the reconstituted (dissolved) protein into several discrete vials in order to avoid repeated freezing and thawing. Reconstituted protein can be stored at 4°C
PubChem LCSS

Semaglutide Laboratory Chemical Safety Summary


InChIInChI=1S/C187H291N45O59/c1-18-105(10)154(180(282)208-108(13)159(261)216-133(86-114-89-200-119-50-40-39-49-117(114)119)170(272)218-129(82-102(4)5)171(273)228-152(103(6)7)178(280)215-121(53-44-72-199-186(192)193)162(264)201-91-141(242)209-120(52-43-71-198-185(190)191)161(263)204-94-151(257)258)230-172(274)131(83-111-45-33-31-34-46-111)219-167(269)126(64-69-149(253)254)214-166(268)122(51-41-42-70-195-144(245)98-290-79-78-289-76-74-197-145(246)99-291-80-77-288-75-73-196-139(240)66-61-127(183(285)286)211-140(241)54-37-29-27-25-23-21-19-20-22-24-26-28-30-38-55-146(247)248)212-158(260)107(12)206-157(259)106(11)207-165(267)125(60-65-138(189)239)210-142(243)92-202-163(265)123(62-67-147(249)250)213-168(270)128(81-101(2)3)217-169(271)130(85-113-56-58-116(238)59-57-113)220-175(277)135(95-233)223-177(279)137(97-235)224-179(281)153(104(8)9)229-174(276)134(88-150(255)256)221-176(278)136(96-234)225-182(284)156(110(15)237)231-173(275)132(84-112-47-35-32-36-48-112)222-181(283)155(109(14)236)227-143(244)93-203-164(266)124(63-68-148(251)252)226-184(287)187(16, 17)232-160(262)118(188)87-115-90-194-100-205-115/h31-36, 39-40, 45-50, 56-59, 89-90, 100-110, 118, 120-137, 152-156, 200, 233-238H, 18-30, 37-38, 41-44, 51-55, 60-88, 91-99, 188H2, 1-17H3, (H2, 189, 239)(H, 194, 205)(H, 195, 245)(H, 196, 240)(H, 197, 246)(H, 201, 264)(H, 202, 265)(H, 203, 266)(H, 204, 263)(H, 206, 259)(H, 207, 267)(H, 208, 282)(H, 209, 242)(H, 210, 243)(H, 211, 241)(H, 212, 260)(H, 213, 270)(H, 214, 268)(H, 215, 280)(H, 216, 261)(H, 217, 271)(H, 218, 272)(H, 219, 269)(H, 220, 277)(H, 221, 278)(H, 222, 283)(H, 223, 279)(H, 224, 281)(H, 225, 284)(H, 226, 287)(H, 227, 244)(H, 228, 273)(H, 229, 276)(H, 230, 274)(H, 231, 275)(H, 232, 262)(H, 247, 248)(H, 249, 250)(H, 251, 252)(H, 253, 254)(H, 255, 256)(H, 257, 258)(H, 285, 286)(H4, 190, 191, 198)(H4, 192, 193, 199)/t105-, 106-, 107-, 108-, 109+, 110+, 118-, 120-, 121-, 122-, 123-, 124-, 125-, 126-, 127+, 128-, 129-, 130-, 131-, 132-, 133-, 134-, 135-, 136-, 137-, 152-, 153-, 154-, 155-, 156-/m0/s1
Isomeric SMILES CC[C@H](C)[C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CNC2=CC=CC=C21)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)O)NC(=O)[C@H](CC3=CC=CC=C3)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCNC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](C(=O)O)NC(=O)CCCCCCCCCCCCCCCCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)N)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC4=CC=C(C=C4)O)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC5=CC=CC=C5)NC(=O)[C@H]([C@@H](C)O)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)C(C)(C)NC(=O)[C@H](CC6=CN=CN6)N
IUPAC Name 18-[[(1R)-4-[2-[2-[2-[2-[2-[2-[[(5S)-5-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S, 3R)-2-[[(2S)-2-[[(2S, 3R)-2-[[2-[[(2S)-2-[[2-[[(2S)-2-amino-3-(1H-imidazol-5-yl)propanoyl]amino]-2-methylpropanoyl]amino]-4-carboxybutanoyl]amino]acetyl]amino]-3-hydroxybutanoyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]-3-carboxypropanoyl]amino]-3-methylbutanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxypropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-4-methylpentanoyl]amino]-4-carboxybutanoyl]amino]acetyl]amino]-5-oxopentanoyl]amino]propanoyl]amino]propanoyl]amino]-6-[[(2S)-1-[[(2S)-1-[[(2S, 3S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-5-carbamimidamido-1-[[2-[[(2S)-5-carbamimidamido-1-(carboxymethylamino)-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-6-oxohexyl]amino]-2-oxoethoxy]ethoxy]ethylamino]-2-oxoethoxy]ethoxy]ethylamino]-1-carboxy-4-oxobutyl]amino]-18-oxooctadecanoic acid


NuScience Peptides sells research products only, they are not for human consumption.

Semaglutide Research Peptide: Facilitating Research in Weight Management

Explore the potential of Semaglutide peptides for impactful weight loss research. Our thoughtfully selected range enhances metabolic function and improves insulin sensitivity, paving the way for transformative studies toward a healthier and leaner future. Commence your research journey into sustainable weight management with Semaglutide peptides today.

Description – Semaglutide

Semaglutide – GLP-1, short for glucagon-like peptide-1 is a short, naturally occurring peptide hormone just 30-31 amino acids in length. Its primary physiologic function is to lower blood sugar levels by naturally enhancing insulin secretion.

It also plays a role in protecting beta cell insulin stores by promoting insulin gene transcription and has been linked with neurotrophic effects in the brain and central nervous system. In the GI system, GLP-1 has been shown to significantly decrease appetite by delaying gastric emptying and reducing intestinal motility. Preliminary research has shown the impacts of GLP-1 in the heart, fat, muscles, bones, liver, lungs, and kidneys as well.

The primary focus of GLP-1 research (Semaglutide) has been in the realm of diabetes treatment/prevention as well as appetite suppression. Secondary research focuses on the potential cardiovascular benefits of the peptide. More recent, and thus less robust, research focuses on the ability of GLP-1 to stave off neurodegenerative disease. Though this latter area of research is the newest, it is also the fast-growing area of GLP-1 study now that the peptide has been revealed to slow or prevent the accumulation of amyloid beta plaques in the setting of Alzheimer’s disease.

The Incretin Effect of GLP-1

Perhaps the most important effect that GLP-1 has, according to Dr. Holst, is referred to as the “incretin effect.” Incretins are a group of metabolic hormones, released by the GI tract, that cause a decrease in blood glucose (sugar) levels. GLP-1 has been shown to be one of the two most important hormones (the other being GIP) to stimulate the incretin effect in rodent models. Though GIP circulates at levels roughly 10 times higher than that of GLP-1 (Semaglutide), there is evidence that GLP-1 is the more potent of the two molecules, particularly when levels of blood glucose are quite high.

GLP-1 and Appetite – Semaglutide

Research in mouse models suggests that GLP-1, such as Semaglutide, administered into the brains of mice may reduce the urge to eat and curb food intake. GLP-1 appears to enhance feelings of satiety, promoting a sense of fullness and indirectly reducing hunger. Recent clinical studies in mice suggest that twice-daily GLP-1 receptor agonist administration, specifically the semaglutide dosage for weight loss, leads to gradual, linear weight loss. Over time, this weight loss is linked to significant improvements in cardiovascular risk factors and a reduction in hemoglobin A1C levels—a key marker reflecting diabetes severity and the effectiveness of blood sugar control achieved through treatment.

Over a long period, this weight loss is associated with significant improvement in cardiovascular risk factors and a reduction in hemoglobin A1C levels, the latter of these being a proxy marker for the severity of diabetes and the quality of blood sugar control attained via treatment.

NuScience Peptides sells research products only, they are not for human consumption.


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Frequently Asked Questions

What is Semaglutide and what are its primary research applications?

Semaglutide is a GLP-1 analogue used primarily in research for its effects on glucose regulation and weight management. It is studied for its potential to lower blood sugar levels and reduce appetite.

Do I need a research institution affiliation to purchase Semaglutide peptides?

Yes, purchasing Semaglutide peptides typically requires an affiliation with a research institution or laboratory. You may need to provide proof of your affiliation during the purchasing process.

Can I return or exchange Semaglutide peptides if they do not meet my research requirements?

Due to the sensitive nature of research chemicals, returns and exchanges are generally not accepted. However, if there is an issue with the quality of the product, please contact our customer service for assistance.

What should I consider before purchasing Semaglutide peptides for my research?

Before buying Semaglutide research peptides, ensure you have a clear research plan, understand the legal requirements for your region, and have the appropriate facilities for handling and storing the peptides.

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