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TB500 Peptide – Research-Grade Thymosin Beta-4 – 5mg | 10mg

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5 | 10 mg per vial

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Properties

Molecular Formula	C₂₁₂H₃₅₀N₅₆O₇₈S
Molecular Weight	4963
Monoisotopic Mass	4960.4863169
Polar Area	220
Complexity	12200
XLogP	-43.5
Heavy Atom Count	347
Hydrogen Bond Donor Count	72
Hydrogen Bond Acceptor Count	88
Rotatable Bond Count	180
Physical Appearance	Fine White Lyophilized Powder
Stability	Lyophilized protein is to be stored at -20°C. It is recommended to aliquot the reconstituted (dissolved) protein into several discrete vials in order to avoid repeated freezing and thawing. Reconstituted protein can be stored at 4°C
PubChem LCSS	Thymosin Beta-4 (TB500) Laboratory Chemical Safety Summary

Identifiers

CID	45382195
CAS	77591-33-4
InChI	InChI=1S/C212H350N56O78S/c1-16-106(7)166(261-190(323)131(64-75-160(292)293)231-172(305)109(10)228-174(307)134(78-91-347-15)245-196(329)140(98-165(302)303)255-201(334)147-53-39-88-266(147)209(342)135(52-29-38-87-221)250-197(330)139(97-164(300)301)254-198(331)143(100-269)229-113(14)276)204(337)246-129(62-73-158(288)289)187(320)233-118(47-24-33-82-216)179(312)252-137(94-114-42-19-18-20-43-114)194(327)253-138(96-163(298)299)195(328)237-121(50-27-36-85-219)181(314)258-144(101-270)199(332)239-119(48-25-34-83-217)178(311)251-136(92-104(3)4)193(326)236-116(45-22-31-80-214)175(308)235-122(51-28-37-86-220)189(322)263-168(110(11)273)207(340)249-133(66-77-162(296)297)192(325)264-169(111(12)274)206(339)248-126(58-69-152(224)279)184(317)243-128(61-72-157(286)287)186(319)234-120(49-26-35-84-218)180(313)256-142(95-153(225)280)211(344)268-90-40-54-148(268)202(335)257-141(93-105(5)6)210(343)267-89-41-55-149(267)203(336)259-145(102-271)200(333)238-117(46-23-32-81-215)177(310)244-132(65-76-161(294)295)191(324)265-170(112(13)275)208(341)262-167(107(8)17-2)205(338)247-130(63-74-159(290)291)188(321)241-125(57-68-151(223)278)183(316)242-127(60-71-156(284)285)185(318)232-115(44-21-30-79-213)176(309)240-124(56-67-150(222)277)173(306)227-108(9)171(304)226-99-154(281)230-123(59-70-155(282)283)182(315)260-146(103-272)212(345)346/h18-20, 42-43, 104-112, 115-149, 166-170, 269-275H, 16-17, 21-41, 44-103, 213-221H2, 1-15H3, (H2, 222, 277)(H2, 223, 278)(H2, 224, 279)(H2, 225, 280)(H, 226, 304)(H, 227, 306)(H, 228, 307)(H, 229, 276)(H, 230, 281)(H, 231, 305)(H, 232, 318)(H, 233, 320)(H, 234, 319)(H, 235, 308)(H, 236, 326)(H, 237, 328)(H, 238, 333)(H, 239, 332)(H, 240, 309)(H, 241, 321)(H, 242, 316)(H, 243, 317)(H, 244, 310)(H, 245, 329)(H, 246, 337)(H, 247, 338)(H, 248, 339)(H, 249, 340)(H, 250, 330)(H, 251, 311)(H, 252, 312)(H, 253, 327)(H, 254, 331)(H, 255, 334)(H, 256, 313)(H, 257, 335)(H, 258, 314)(H, 259, 336)(H, 260, 315)(H, 261, 323)(H, 262, 341)(H, 263, 322)(H, 264, 325)(H, 265, 324)(H, 282, 283)(H, 284, 285)(H, 286, 287)(H, 288, 289)(H, 290, 291)(H, 292, 293)(H, 294, 295)(H, 296, 297)(H, 298, 299)(H, 300, 301)(H, 302, 303)(H, 345, 346)
InChIKey	UGPMCIBIHRSCBV-UHFFFAOYSA-N
Isomeric SMILES	CC[C@H](C)[C@@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)N)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]4CCCN4C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)C
Canonical SMILES	CCC(C)C(C(=O)NC(CCC(=O)O)C(=O)NC(CCCCN)C(=O)NC(CC1=CC=CC=C1)C(=O)NC(CC(=O)O)C(=O)NC(CCCCN)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(C(C)O)C(=O)NC(CCC(=O)O)C(=O)NC(C(C)O)C(=O)NC(CCC(=O)N)C(=O)NC(CCC(=O)O)C(=O)NC(CCCCN)C(=O)NC(CC(=O)N)C(=O)N2CCCC2C(=O)NC(CC(C)C)C(=O)N3CCCC3C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCC(=O)O)C(=O)NC(C(C)O)C(=O)NC(C(C)CC)C(=O)NC(CCC(=O)O)C(=O)NC(CCC(=O)N)C(=O)NC(CCC(=O)O)C(=O)NC(CCCCN)C(=O)NC(CCC(=O)N)C(=O)NC(C)C(=O)NCC(=O)NC(CCC(=O)O)C(=O)NC(CO)C(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C(C)NC(=O)C(CCSC)NC(=O)C(CC(=O)O)NC(=O)C4CCCN4C(=O)C(CCCCN)NC(=O)C(CC(=O)O)NC(=O)C(CO)NC(=O)C
IUPAC Name	4-[[2-[2-[[2-[[2-[[2-[[2-[[2-[[2-[[2-[[2-[[2-[[2-[[1-[2-[[1-[2-[[2-[[2-[[2-[[2-[[2-[[2-[[2-[[2-[[2-[[2-[[2-[[2-[[2-[[2-[[2-[[2-[[2-[[2-[2-[[2-[[2-[[1-[2-[[2-[(2-acetamido-3-hydroxypropanoyl)amino]-3-carboxypropanoyl]amino]-6-aminohexanoyl]pyrrolidine-2-carbonyl]amino]-3-carboxypropanoyl]amino]-4-methylsulfanylbutanoyl]amino]propanoylamino]-4-carboxybutanoyl]amino]-3-methylpentanoyl]amino]-4-carboxybutanoyl]amino]-6-aminohexanoyl]amino]-3-phenylpropanoyl]amino]-3-carboxypropanoyl]amino]-6-aminohexanoyl]amino]-3-hydroxypropanoyl]amino]-6-aminohexanoyl]amino]-4-methylpentanoyl]amino]-6-aminohexanoyl]amino]-6-aminohexanoyl]amino]-3-hydroxybutanoyl]amino]-4-carboxybutanoyl]amino]-3-hydroxybutanoyl]amino]-5-amino-5-oxopentanoyl]amino]-4-carboxybutanoyl]amino]-6-aminohexanoyl]amino]-4-amino-4-oxobutanoyl]pyrrolidine-2-carbonyl]amino]-4-methylpentanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxypropanoyl]amino]-6-aminohexanoyl]amino]-4-carboxybutanoyl]amino]-3-hydroxybutanoyl]amino]-3-methylpentanoyl]amino]-4-carboxybutanoyl]amino]-5-amino-5-oxopentanoyl]amino]-4-carboxybutanoyl]amino]-6-aminohexanoyl]amino]-5-amino-5-oxopentanoyl]amino]propanoylamino]acetyl]amino]-5-[(1-carboxy-2-hydroxyethyl)amino]-5-oxopentanoic acid

Description

This product is not intended for weight loss, human consumption, or veterinary use. It is sold for research purposes only. Please handle with care and follow all safety guidelines for the specific chemicals involved.

What is TB500 (Thymosin Beta-4)

TB-500, also known as Thymosin Beta 4, is a synthetic peptide derived from a naturally occurring protein found in most mammalian tissues1. This peptide is known for stimulating muscle growth, regeneration, and wound healing3. In research, TB500 (Thymosin Beta-4) has been identified as a key mediator in cellular proliferation and differentiation, as well as a modulator of the inflammatory response. Researchers have found that TB500 (Thymosin Beta-4) is a potent promoter of wound healing3 and modulator of the inflammatory response of animal test subjects4. Its ability to regulate the production of actin, a crucial component for cellular structure and movement, highlights its broad spectrum of beneficial capabilities in various biological processes.

Effects of TB-500 Demonstrated in Recent Studies

Recent studies on TB-500 (Thymosin Beta 4) have shown potential benefits, including promoting endothelial cell differentiation, angiogenesis in dermal tissues, and keratinocyte migration. The peptide may also enhance collagen deposition, reduce joint inflammation, increase muscle growth, and improve muscle tone and endurance. Additionally, TB500 (Thymosin Beta-4) has been found to relax muscle spasms, promote tissue repair, increase cellular exchange, and help maintain flexibility by stretching connective tissue. It also aids in preventing the formation of adhesions and fibrous bands in muscles, tendons, and ligaments.

Purely for Scientific Research

While significant research has been conducted on TB500 (Thymosin Beta-4), it is crucial to note that this peptide is intended solely for scientific study. Any findings or observations related to TB-500’s functionality, mechanics, or benefits should be derived exclusively from controlled research environments.

Muscle Repair and Maintenance – TB500

TB500 (Thymosin Beta-4) has been researched extensively in the areas of muscle and connective tissue repair⁵. TB500 (Thymosin Beta-4) has been shown to stimulate the overproduction of regenerative fibers following injury, thereby speeding the process of recovery with minimal inflammation and residual scarification.

TB500’s property of enhancing muscle growth in both healthy and damaged tissues has led to its application as an experimental therapeutic in animal test subjects with muscular dystrophy⁶. Regular administration of TB500 (Thymosin Beta-4) allowed animal test subjects with muscular dystrophy to achieve much improved maintenance of muscle growth and development, even in the absence of important, naturally occurring proteins that usually guide this action.

TB500 (Thymosin Beta-4) has also been researched to be an aid in the healing of heart tissue following heart attack⁷ and as a very powerful agent for quickly healing skin abrasions. TB500’s angiogenic (blood vessel-forming) properties⁸ are responsible for its excellent application in these areas.

NuScience Peptides sells research products only, they are not for human consumption.

Synonyms:

Thymosin Beta 4; TB500; TB-500

Peer-Reviewed Sources:

Safer, D., Elzinga, M., & Nachmias, V. T. (1991). Thymosin beta 4 and Fx, an actin-sequestering peptide, are indistinguishable. Journal of Biological Chemistry, 266(7), 4029-4032.
Grant, D. S., Kinsella, J. L., Kibbey, M. C., LaFlamme, S., Burbelo, P. D., Goldstein, A. L., & Kleinman, H. K. (1995). Matrigel induces thymosin beta 4 gene in differentiating endothelial cells. Journal of cell science, 108(12), 3685-3694.
Malinda, K. M., Sidhu, G. S., Mani, H., Banaudha, K., Maheshwari, R. K., Goldstein, A. L., & Kleinman, H. K. (1999). Thymosin β4 accelerates wound healing. Journal of investigative dermatology, 113(3), 364-368.
Sosne, G., Szliter, E. A., Barrett, R., Kernacki, K. A., Kleinman, H., & Hazlett, L. D. (2002). Thymosin beta 4 promotes corneal wound healing and decreases inflammation in vivo following alkali injury. Experimental eye research,74(2), 293-299.
Blain, E. J., Mason, D. J., & Duance, V. C. (2002). The effect of thymosin beta4 on articular cartilage chondrocyte matrix metalloproteinase expression. Biochemical Society Transactions, 30(Pt 6), 879-882.
Spurney, C. F., Cha, H. J., Sali, A., Pandey, G. S., Pistilli, E., Guerron, A. D., & Nagaraju, K. (2010). Evaluation of Skeletal and Cardiac Muscle Function after Chronic Administration of Thymosin β-4 in the Dystrophin Deficient Mouse. PloS one, 5(1), e8976.
Crockford, D. (2007). Development of thymosin β4 for treatment of patients with ischemic heart disease. Annals of the New York Academy of Sciences, 1112(1), 385-395.
Smart, N., Rossdeutsch, A., & Riley, P. R. (2007). Thymosin β4 and angiogenesis: modes of action and therapeutic potential. Angiogenesis, 10(4), 229-241.

ALL LITERATURE, INFORMATION, AND DATA, PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY.

Accurate research is our number one priority.

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Frequently Asked Questions

Everything you need to know about TB-500

1
What is TB-500?

TB-500 (Thymosin Beta-4) is a 43-amino acid peptide that has been researched extensively for muscle and connective tissue repair, with properties including promoting endothelial cell differentiation and angiogenesis.

2
What sizes are available for TB-500?

TB-500 is available in 5mg and 10mg vials.

3
What benefits have been demonstrated in recent studies?

Studies show TB-500 may promote angiogenesis, enhance collagen deposition, reduce joint inflammation, increase muscle growth and tone, relax muscle spasms, promote tissue repair, and help maintain flexibility in connective tissue.

4
How has TB-500 been studied for muscle repair?

Research shows TB-500 stimulates overproduction of regenerative fibers following injury, speeding recovery with minimal inflammation and scarification. It has been applied experimentally in animal subjects with muscular dystrophy.

5
What other applications have been researched?

TB-500 has been researched as an aid in healing heart tissue following a heart attack and as an agent for quickly healing skin abrasions, due to its angiogenic (blood vessel-forming) properties.

6
How should TB-500 be stored?

Lyophilized TB-500 should be stored at -20°C. After reconstitution, aliquot into several discrete vials to avoid repeated freezing and thawing. Reconstituted protein can be stored at 4°C.