TB500 (Thymosin Beta-4) – 5mg


5 mg per vial

Rated 5.0 out of 5
5.0 out of 5 stars (based on 5 reviews)
Very good0%
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Fantastic Service

Rated 5.0 out of 5
December 17, 2023

All emails returned and answered quickly. Even on Sunday. Shipping was done within hours of placing the order.

Priced very fair.

Al Morris

Response from NuScience Peptides

Thank you!! We strive for the best customer experience from order to delivery!!

5 -star customer service !!

Rated 5.0 out of 5
September 24, 2023

What business answers the phone on Sunday during football? NuScience that’s who!!! Thanks for helping me out with processing my order and changing my address. Products came in 3 days., can’t ask for more than that.

Charlie G.

Great price and quick delivery

Rated 5.0 out of 5
September 15, 2023

Wonderful price and very quick delivery!! Thanks Nuscience! I plan on ordering more soon!🙂


Response from NuScience Peptides

Thank for the review, we strive to give top notch customer service while providing a premium product!!!

whoop there it is

Rated 5.0 out of 5
July 29, 2023

Wow, I’m impressed with how fast my order arrived! It was delivered well before the estimated delivery date. Kudos to the efficient delivery and for their speed.

Thompson team

Response from NuScience Peptides

We try to ship same day given the opportunity!

Thank you NuScience

Rated 5.0 out of 5
July 18, 2023

Order and delivered in 72 hours.



Molecular Formula


Molecular Weight4963
Monoisotopic Mass4960.4863169
Polar Area220
Heavy Atom Count347
Hydrogen Bond Donor Count72
Hydrogen Bond Acceptor Count88
Rotatable Bond Count180
Physical AppearanceFine White Lyophilized Powder
StabilityLyophilized protein is to be stored at -20°C. It is recommended to aliquot the reconstituted (dissolved) protein into several discrete vials in order to avoid repeated freezing and thawing. Reconstituted protein can be stored at 4°C
PubChem LCSS

Thymosin Beta-4 (TB500) Laboratory Chemical Safety Summary


InChIInChI=1S/C212H350N56O78S/c1-16-106(7)166(261-190(323)131(64-75-160(292)293)231-172(305)109(10)228-174(307)134(78-91-347-15)245-196(329)140(98-165(302)303)255-201(334)147-53-39-88-266(147)209(342)135(52-29-38-87-221)250-197(330)139(97-164(300)301)254-198(331)143(100-269)229-113(14)276)204(337)246-129(62-73-158(288)289)187(320)233-118(47-24-33-82-216)179(312)252-137(94-114-42-19-18-20-43-114)194(327)253-138(96-163(298)299)195(328)237-121(50-27-36-85-219)181(314)258-144(101-270)199(332)239-119(48-25-34-83-217)178(311)251-136(92-104(3)4)193(326)236-116(45-22-31-80-214)175(308)235-122(51-28-37-86-220)189(322)263-168(110(11)273)207(340)249-133(66-77-162(296)297)192(325)264-169(111(12)274)206(339)248-126(58-69-152(224)279)184(317)243-128(61-72-157(286)287)186(319)234-120(49-26-35-84-218)180(313)256-142(95-153(225)280)211(344)268-90-40-54-148(268)202(335)257-141(93-105(5)6)210(343)267-89-41-55-149(267)203(336)259-145(102-271)200(333)238-117(46-23-32-81-215)177(310)244-132(65-76-161(294)295)191(324)265-170(112(13)275)208(341)262-167(107(8)17-2)205(338)247-130(63-74-159(290)291)188(321)241-125(57-68-151(223)278)183(316)242-127(60-71-156(284)285)185(318)232-115(44-21-30-79-213)176(309)240-124(56-67-150(222)277)173(306)227-108(9)171(304)226-99-154(281)230-123(59-70-155(282)283)182(315)260-146(103-272)212(345)346/h18-20, 42-43, 104-112, 115-149, 166-170, 269-275H, 16-17, 21-41, 44-103, 213-221H2, 1-15H3, (H2, 222, 277)(H2, 223, 278)(H2, 224, 279)(H2, 225, 280)(H, 226, 304)(H, 227, 306)(H, 228, 307)(H, 229, 276)(H, 230, 281)(H, 231, 305)(H, 232, 318)(H, 233, 320)(H, 234, 319)(H, 235, 308)(H, 236, 326)(H, 237, 328)(H, 238, 333)(H, 239, 332)(H, 240, 309)(H, 241, 321)(H, 242, 316)(H, 243, 317)(H, 244, 310)(H, 245, 329)(H, 246, 337)(H, 247, 338)(H, 248, 339)(H, 249, 340)(H, 250, 330)(H, 251, 311)(H, 252, 312)(H, 253, 327)(H, 254, 331)(H, 255, 334)(H, 256, 313)(H, 257, 335)(H, 258, 314)(H, 259, 336)(H, 260, 315)(H, 261, 323)(H, 262, 341)(H, 263, 322)(H, 264, 325)(H, 265, 324)(H, 282, 283)(H, 284, 285)(H, 286, 287)(H, 288, 289)(H, 290, 291)(H, 292, 293)(H, 294, 295)(H, 296, 297)(H, 298, 299)(H, 300, 301)(H, 302, 303)(H, 345, 346)
Isomeric SMILESCC[C@H](C)[C@@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)N)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]4CCCN4C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)C
IUPAC Name4-[[2-[2-[[2-[[2-[[2-[[2-[[2-[[2-[[2-[[2-[[2-[[2-[[1-[2-[[1-[2-[[2-[[2-[[2-[[2-[[2-[[2-[[2-[[2-[[2-[[2-[[2-[[2-[[2-[[2-[[2-[[2-[[2-[[2-[2-[[2-[[2-[[1-[2-[[2-[(2-acetamido-3-hydroxypropanoyl)amino]-3-carboxypropanoyl]amino]-6-aminohexanoyl]pyrrolidine-2-carbonyl]amino]-3-carboxypropanoyl]amino]-4-methylsulfanylbutanoyl]amino]propanoylamino]-4-carboxybutanoyl]amino]-3-methylpentanoyl]amino]-4-carboxybutanoyl]amino]-6-aminohexanoyl]amino]-3-phenylpropanoyl]amino]-3-carboxypropanoyl]amino]-6-aminohexanoyl]amino]-3-hydroxypropanoyl]amino]-6-aminohexanoyl]amino]-4-methylpentanoyl]amino]-6-aminohexanoyl]amino]-6-aminohexanoyl]amino]-3-hydroxybutanoyl]amino]-4-carboxybutanoyl]amino]-3-hydroxybutanoyl]amino]-5-amino-5-oxopentanoyl]amino]-4-carboxybutanoyl]amino]-6-aminohexanoyl]amino]-4-amino-4-oxobutanoyl]pyrrolidine-2-carbonyl]amino]-4-methylpentanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxypropanoyl]amino]-6-aminohexanoyl]amino]-4-carboxybutanoyl]amino]-3-hydroxybutanoyl]amino]-3-methylpentanoyl]amino]-4-carboxybutanoyl]amino]-5-amino-5-oxopentanoyl]amino]-4-carboxybutanoyl]amino]-6-aminohexanoyl]amino]-5-amino-5-oxopentanoyl]amino]propanoylamino]acetyl]amino]-5-[(1-carboxy-2-hydroxyethyl)amino]-5-oxopentanoic acid


NuScience Peptides sells research products only, they are not for human consumption.

Description – TB500

TB500 is a synthetic analogue to a naturally occurring protein present in most kinds of mammalian tissue1. TB500 is an active mediating agent in cellular proliferation and differentiation processes2. Researchers have found that TB-500 is a potent promoter of wound healing3 and modulator of the inflammatory response of animal test subjects4. Through its action of regulating the production of actin, an important cellular component involved in structure and movement of all cells, TB-500 is an agent with a broad spectrum of beneficial capabilities.

Muscle Repair and Maintenance – TB500

TB500 has been researched extensively in the areas of muscle and connective tissue repair5. TB500 has been shown to stimulate the overproduction of regenerative fibers following injury, thereby speeding the process of recovery with minimal inflammation and residual scarification.

TB500’s property of enhancing muscle growth in both healthy and damaged tissues has led to its application as an experimental therapeutic in animal test subjects with muscular dystrophy6. Regular administration of TB500 allowed animal test subjects with muscular dystrophy to achieve much improved maintenance of muscle growth and development, even in the absence of important, naturally occurring proteins that usually guide this action.

TB500 has also been researched to be an aid in the healing of heart tissue following heart attack7 and as a very powerful agent for quickly healing skin abrasions. TB500’s angiogenic (blood vessel-forming) properties8 are responsible for its excellent application in these areas.

NuScience Peptides sells research products only, they are not for human consumption.


Thymosin Beta 4; TB500; TB-500

Peer-Reviewed Sources:

  1. Safer, D., Elzinga, M., & Nachmias, V. T. (1991). Thymosin beta 4 and Fx, an actin-sequestering peptide, are indistinguishable. Journal of Biological Chemistry, 266(7), 4029-4032.
  2. Grant, D. S., Kinsella, J. L., Kibbey, M. C., LaFlamme, S., Burbelo, P. D., Goldstein, A. L., & Kleinman, H. K. (1995). Matrigel induces thymosin beta 4 gene in differentiating endothelial cells. Journal of cell science, 108(12), 3685-3694.
  3. Malinda, K. M., Sidhu, G. S., Mani, H., Banaudha, K., Maheshwari, R. K., Goldstein, A. L., & Kleinman, H. K. (1999). Thymosin β4 accelerates wound healing. Journal of investigative dermatology, 113(3), 364-368.
  4. Sosne, G., Szliter, E. A., Barrett, R., Kernacki, K. A., Kleinman, H., & Hazlett, L. D. (2002). Thymosin beta 4 promotes corneal wound healing and decreases inflammation in vivo following alkali injury. Experimental eye research,74(2), 293-299.
  5. Blain, E. J., Mason, D. J., & Duance, V. C. (2002). The effect of thymosin beta4 on articular cartilage chondrocyte matrix metalloproteinase expression. Biochemical Society Transactions, 30(Pt 6), 879-882.
  6. Spurney, C. F., Cha, H. J., Sali, A., Pandey, G. S., Pistilli, E., Guerron, A. D., & Nagaraju, K. (2010). Evaluation of Skeletal and Cardiac Muscle Function after Chronic Administration of Thymosin β-4 in the Dystrophin Deficient Mouse. PloS one, 5(1), e8976.
  7. Crockford, D. (2007). Development of thymosin β4 for treatment of patients with ischemic heart disease. Annals of the New York Academy of Sciences, 1112(1), 385-395.
  8. Smart, N., Rossdeutsch, A., & Riley, P. R. (2007). Thymosin β4 and angiogenesis: modes of action and therapeutic potential. Angiogenesis, 10(4), 229-241.


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